ChemicalBook CAS DataBase List 621-72-7

621-72-7

Name	Bendazol
CAS	621-72-7
EINECS(EC#)	210-703-6
Molecular Formula	C14H12N2
MDL Number	MFCD00022680
Molecular Weight	208.26
MOL File	621-72-7.mol

Chemical Properties

Melting point	187°
Boiling point	337.46°C (rough estimate)
density	1.1345 (rough estimate)
refractive index	1.6152 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO
form	Solid
pka	11.77±0.10(Predicted)
color	Crystals or needles from benzene
CAS DataBase Reference	621-72-7(CAS DataBase Reference)

Safety Data

HazardClass	IRRITANT
Toxicity	LD50 orl-mus: 100 mg/kg FRZKAP (1),44,83 less more

Raw materials And Preparation Products

Hazard Information

Uses

Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats[1][2][3].

Definition

ChEBI: Bendazol is a member of benzimidazoles.

Safety Profile

Poison by ingestion andintraperitoneal routes. Moderately toxic by subcutaneousroute. Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx.

in vivo

Bendazol (1%; Eye drops; Four times daily for 6 weeks) significantly inhibits the development of myopia and down-regulates the expression of HIF-1α in experimental myopia rabbit models^[1].
Bendazol (0.1 mg/kg; Intraperitoneal injection; 2 weeks) regulates kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension^[2].

Animal Model:	New Zealand white rabbits aged 3 weeks old with experimental myopia^[1]
Dosage:	1%
Administration:	Eye drops; Four times daily for 6 weeks
Result:	Inhibited the progression of form-deprivation myopia. Suppressed the upregulation of HIF-1α.

Animal Model:	Paraformaldehyde (HY-Y0333) treated mature random-bred male rats (250-280 g)^[2]
Dosage:	0.1 mg/kg
Administration:	Intraperitoneal injection (i.p.); 2 weeks
Result:	Remained NADPH diaphorase activity in PT epitheliocytes near the control level throughout the experiment; Gradually increased NADPH diaphorase activity in DT epitheliocytes to the control level throughout the experiment. Enhanced NADPH diaphorase activity and maintained it elevated in renal glomeruli throughout the experiment; Increased NADPH diaphorase in the collecting tubules, but thereupon it declined to the control level at the end of experimental. Insignificant enhanced of NOS activity in PT epitheliocytes observed on postinjection week 1 can somewhat contribute to upregulation of natriuresis and diuresis.

IC 50

HIF-1α

References

[1] Tong L, et al. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits. Ophthalmic Physiol Opt. 2020 Sep;40(5):567-576. DOI:10.1111/opo.12717
[2] Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361. DOI:10.1007/s10517-017-3615-3
[3] Kuzubova EA, et al. [Effect of dibazol (bendazol) on the generative function in rats]. Eksp Klin Farmakol. 2007 Mar-Apr;70(2):37-9. PMID:17523449

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